Sim has written 5 posts for cell fate, ageing and decay

Collaboration Paper: Cell Metabolism

Chakravarthy et al. dissect the mechanisms maintaining α cell identity and reveal that simultaneous inactivation of the DNA methyltransferase Dnmt1 and the transcription factor Arx in adult mice drives the conversion of α- to β-like cells. In human T1D islets, glucagon+ cells lose DNMT1 and ARX expression and express β cell markers.

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Review: Diabetes, Obesity and Metabolism

Here, we discuss the latest findings on pancreas and islet cell plasticity upon physiological, pathological and experimental conditions of stress. Understanding the mechanisms involved in cell reprogramming will allow the development of new strategies for the treatment of diabetes, by exploiting the intrinsic regeneration capacity of the pancreas.

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Review: Current Opinion in Genetics & Development

The prevalence of diabetes will rise from 2.8% of the total world population in 2000 to 4.4% in 2030. The two prevailing forms of diabetes, named Type 1 and Type 2 (T1D and T2D), are chronic and often lead to life-threatening complications. There is currently no cure for diabetes, due to the poorly understood complex … Continue reading

Interview on UiB website

If you want to read about our research featured in an article published on the News of University of Bergen, please click on the following link: Studying single-gene disorders to cure diabetes    

FRIPRO Young Talent Research Project

The Norwegian Research Council announced on 7th of December the new list of awardees. We got new funding from FRIPRO for another independent Young Research Talent project: “Characterizing and modulating the insulin-producing beta-cell fate in monogenic diabetes by using novel genetic setups” The risk of developing certain disorders increments with age, nearly all life limiting … Continue reading

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